https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45083 cis-regulatory elements and their associated trans-acting factors. Where these components aggregate in promoters and enhancers, they are able to cooperate to modulate chromatin structure and support the engagement in long-range 3D superstructures that shape the dynamics of a cell's genomic architecture. Recently, the term 'super-enhancer' has been introduced to describe a hyper-active regulatory domain comprising a complex array of sequence elements that work together to control the key gene networks involved in cell identity. Here, we survey the unique characteristics of super-enhancers compared to other enhancer types and summarize the recent advances in our understanding of their biological role in gene regulation. In particular, we discuss their capacity to attract the formation of phase-separated condensates, and capacity to generate three-dimensional genome structures that precisely activate their target genes. We also propose a multi-stage transition model to explain the evolutionary pressure driving the development of super-enhancers in complex organisms, and highlight the potential for involvement in tumorigenesis. Finally, we discuss more broadly the role of super-enhancers in human health disorders and related potential in therapeutic interventions.]]> Wed 26 Oct 2022 12:02:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15118 Wed 11 Apr 2018 09:18:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52015 Tue 26 Sep 2023 11:42:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14818 Thu 12 Apr 2018 13:24:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26724 Sat 24 Mar 2018 07:26:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18698 Mon 20 Jul 2015 17:48:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48732 Fri 31 Mar 2023 09:37:21 AEDT ]]>